Google says it has made a significant step in identifying disease-causing genes, which could help spot rare genetic disorders. A new model named AlphaMissense is able to confidently classify 89 per cent of all possible “missense” variants in genes, identifying whether they are likely to cause diseases or benign. That compares with just 0.1 per cent of all missense variants that have been confidently classified by human experts. Missense variants happen when a single letter is substituted in the DNA, which in turn leads to proteins with a different amino acid. That small change can have significant effects – Google likened it to the way that changing a letter in one word can change the meaning of the whole sentence. Most of those variants are benign: the average person has more than 9,000 of them. But some of them can be disastrous, leading to rare genetic diseases. The new AlphaMissense looked at existing information about missense variants, and how commonly they are seen in humans and closely-related primates. It looked for those that were rarely seen, classifying them as pathogenic, and from that was able to use that information to analyse other protein sequences – giving not just a verdict on whether they were likely to cause problems, but also how confident it was. Experiments, conducted by humans, which look to find those mutations are expensive and slow: they require people to examine each unique protein and designed separately. Google says that the new system means that researchers can “preview” those results for thousands of proteins at a time, helping them decide where to focus. The company has used its systems to release a vast catalogue of “missense” mutations, so that researchers can learn about what effect they have. In some cases, those variations can lead to conditions such as cystic fibrosis, sickle-cell anaemia, or cancer, and understanding them could be key to researchers studying ways to treat or prevent those diseases. It is just the latest health breakthrough from Google’s Deepmind division, which is looking to use artificial intelligence to both identify and treat a variety of conditions. The new system was built on AlphaFold, the breakthrough model that helped unfold proteins, the building blocks of life. The research is described in a new paper, ‘Accurate proteome-wide missense variant effect prediction with AlphaMissense’, published in the journal Science. The catalogue is being made “freely available to the research community”, Google said, and the company will release the code behind the AI system. Read More BBC removes some Russell Brand content as monetisation suspended on YouTube Google Bard can now link to Gmail and other apps to help with responses Long-form video content is here to stay, says YouTube UK boss

LOUISVILLE, Ky.--(BUSINESS WIRE)--May 22, 2023--

SAN JOSE, Calif.--(BUSINESS WIRE)--Sep 13, 2023--

DrLupo got an iconic Fortnite Chapter 1 prop from Dusty Diner from Epic Games ahead of the rumored Fortnite OG season launching on Nov. 3, 2023.

MrBeast has hit out against YouTubers who photoshop fake tweets of his and use them in their video thumbnails to try and boost views. In a tweet, the 25-year-old took to Twitter where he called out the clickbait - this is when creators use sensationalised or misleading headlines to reel audiences in. First, he posted a screenshot of a video thumbnail by YouTuber Bolo showing an alleged tweet by MrBeast claiming that he will be dead within the next three years, with the titled called: "MrBeast's Disease Is Worse Than You Think," about MrBeast's Crohn's disease diagnosis. Sign up to our free Indy100 weekly newsletter Along with this image, MrBeast wrote: "Thank god for this YouTube video or I wouldn’t have known I’m dying in three years." Then in a follow-up tweet, he added: "Can we end the trend of Photoshopping fake tweets of mine as thumbnails? Thnx [Thanks]." The response sparked a discussion online about clickbait on YouTube videos. Some people didn't feel too sympathetic towards YouTube's biggest creator. "Going viral comes with a cost. Maybe this is part of the cost," one person wrote. Another person said: "Wait.. so since you're famous now you are calling out clickbait thumbnails?? look in the mirror my guy LOL." Though many tweeted their support for MrBeast and criticised the clickbait methods some creators use to try to drive engagement. One person said: "Tbh it would be very annoying if someone made a tweet I never made." "How can they do that for a little bit more views. They are just playing with people's emotions," another person wrote. Someone else added: "I hate this, but by posting this you have given them more clout." "It’s so scary to me that people would go out of their way to Photoshop images like that and put them out into the universe…" a fourth person commented. Elsewhere, MrBeast has been accused of playing a ‘cruel’ prank on kids in the latest challenge and MrBeast wants to make a Netflix quiz show with the 'biggest prize ever'. "Have your say in our news democracy. Click the upvote icon at the top of the page to help raise this article through the indy100 rankings.

To track their Apex Legends Heirloom progress, players must monitor how many Apex Packs they open on a third-party website.

HOUSTON--(BUSINESS WIRE)--May 18, 2023--

Tens of thousands of protesters took to New York City streets on Sunday to call for an end

By Yuvraj Malik (Reuters) -IBM said on Monday it will acquire technology spend-management platform Apptio from Vista Equity Partners for

More than a 1,000 firefighters are tackling a blaze in the south of Portugal, while Spain braces for

LINCOLNSHIRE, Ill.--(BUSINESS WIRE)--Jun 20, 2023--

Debris found in search for F-35 military jet that went missing after pilot ejected over South Carolina - US officials